关键词: 甲醛； β?丙内酯； 胍基离序盐； 补骨脂素； 过氧化氢； 病毒灭活

Abstract: Virus inactivation is the process of using physical or chemical methods to make the virus lose infectivity. The virus inactivation efficiency is often affected by many factors，such as virus characteristics，types of inactivators and the aims of inactivation. The selection of inactivators is usually determined by the characteristics of the virus and its use after inactivation. Vaccine development requires complete inactivation of the virus while maintaining the integrity of the viral protective antigen epitope structure to induce an effective host immune response. Molecular biological detection requires complete viral genome integrity. Therefore，selecting appropriate inactivators to inactivate highly pathogenic pathogens is an important guarantee for subsequent work such as pathogen molecular diagnosis， serological analysis，and vaccine development. At present，more and more virus inactivators are being developed and utilized. In this paper，5 chemical virus inactivators frequently used are selected，namely formaldehyde，β ? propiolactone，guanidium based chaotropic salts，psoralen，hydrogen peroxide，the inactivation mechanism and inactivation characteristics of the aboved virus inactivators，along with the application of inactivated virus are summarized as follows.

Key words: Formaldehyde； β ? propiolactone； Guanidium based chaotropic salts； Psoralen； Hydrogen peroxide； Virus inactivation